Evaluation of Central Nervous System Infections in Medicolegal Autopsies
DOI:
https://doi.org/10.17986/blm.200491531Keywords:
central nervous system infection, autopsyAbstract
The aim of our retrospective study is to present the histopathological features of central nervous system infections 103 central nervous system infections determined at autopsies, performed in Forensic Medicine Council from 1998 to 2002 were analysed. Cases were classified according to age, gender, microscopic features of brain infection and the cause of death. Microscopically, cases were classified as encephalitis and meningitis. Also brain abcesses and serebritis were evaluated. In 50,4% of our cases the cause of death was natural, and 49,6% were classified as trauma complications. 85 were (83,3%) male and 18 (16,6%) were female. Microscopically we found meningitis at 73 cases (70,87%), 60 (58,25%) of them were bacterial in origin, 8 cases (%7,76%) were lymphocytic, 5 cases (4,85%) were chronic granulomatous meningitis. One nocardia and 4 tuberculosis meningitis were found in chronic granulomatous meningitis group. 19 cases of encephalitis (18,44%) were found. Five cases (4,85%) were diagnosed as encephalitis due to Rabies, 1 case (0,97%) as HIV encephalitis, 1 case (0,97%) as PMLE, 4 cases (3,88%) as Prion disease and 3 cases (2,91%) had meningoencephalitis. Eight cases (7,76%) were classified as NOS encephalitis since any étiologie agent could be isolated. One of the 6 cases (5,82%) diagnosed as brain abcesses was mycotic. 2 cases (1,94%) with nonsuppurative serebritis were found. Pathology of the central nervous system infections is very complex and overlapping. In conclusion, it needs a multidiscip-lianary laboratory investigations in the pathology of infections diseases.
Key words: Central nervous system infection, autopsy
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References
Love S, Wiley CA. Viral diseases in Graham DI, Lantos PL (eds): Greenfield’s Neuropathology, vol 2. London: Arnold Publishers, 2002;l-70.
Cotran R, Kumar V, Robbins S (eds). Infectious diseases in Pathologic Basis of Disease. 5 th ed, W.B: Saunders Company, 1994;305-379.
Matschke J, Tsokos: Post-traumatic meningitis: histo- morphological findings, postmortem microbiology and forensic implications. Forensic Sei Int 2001;115(3):199-205. DOI: https://doi.org/10.1016/S0379-0738(00)00328-5
Nicolosi A, Hauser WA, Musicco M et al: Incidence and prognosis of brain abscess in a defined population: Olmsted County, Minnesota, 1935,1981. Neuroepidemiology 1991; 10(3): 122-31. DOI: https://doi.org/10.1159/000110257
Peakman M, Vergani D (eds): Human immunodeficiency virus and AIDS in Basic and Clinical Immunology. 1 ed, London: Churchill Livingstone, 1997;277-286.
Lanjevar DN, Jain PP, Shetty CR: Profile of central nervous system pathology in patients with AIDS: an autopsy study from India. AIDS 1998;1(3):309-313. DOI: https://doi.org/10.1097/00002030-199803000-00009
Mossakowski MJ, /elman IB: Pathomorphological variations of the AIDS-associated progressive multifocal leukoen- cephalopathy. Folia Neuropathol 2000;38(3):91-100.
Alan CJ, Hongtao Y, Ridaura C: Quantitative study of the infection in brain neurons in human rabies. J Med Virol 2001;65:614-18. DOI: https://doi.org/10.1002/jmv.2080
Iraj D: Is the Negri body spesific for rabies. Arch Neurol 1975;32:75-79. DOI: https://doi.org/10.1001/archneur.1975.00490440025002
Ersoy G, Karayel F, Toprak S: Creutzfeld-Jakob hastalığı; otopsi bulguları ve genel bilgilerin değerlendirilmesi. Adli Tıp Dergisi 2003;17:8-11.
DeArmond SJ, Prusiner SB: Etiology and pathogenesis of prion disease. Am J Pathol 1995;146:785-811.
Öz B, Ersoy G, Demirkesen C: Creutzfeldt-Jakob hastalığı: Otopsi bulguları ve literatürün gözden geçirilmesi. Cerrahpaşa Tıp Dergisi 2000;31(l):42-8.
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