Yara Yaşı ve Canlılık Değerlendirmesinde Güncel Yaklaşım

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Ishida Y, Kondo T, Takayasu T, Iwakura Y, Mukaida N.The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. J Immunol 2004:1;172(3):1848-55. DOI: https://doi.org/10.4049/jimmunol.172.3.1848

Mori R, Kondo T, Ohshima T, Ishida Y, Mukaida N.Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. FASEB J. 2002: 16(9):963-74. DOI: https://doi.org/10.1096/fj.01-0776com

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Kondo T, Ohshima T, Mori R, Guan DW, Ohshima K, Eisenmenger W. Immunohistochemical detection of chemokines in human skin wounds and its application to wound age determination. Int J Legal Med 2002;116:87–91. DOI: https://doi.org/10.1007/s004140100260

Takamiya M, Saigusa K, Nakayashiki N, Aoki Y. Studies on mRNA expression of basic fibroblast growth factor in wound healing for wound age determination. Int J Legal Med 2003;117:46–50.

Takamiya M, Saigusa K, Aoki Y. Immunohistochemical study of basic fibroblast growth factor and vascular endothelial growth factor expression for age determination of cutaneous wounds. Am J Forensic Med Pathol 2002;23:264–7. DOI: https://doi.org/10.1097/00000433-200209000-00012

Hayashi T, Ishida Y, Kimura A, Takayasu T, Eisenmenger W, Kondo T. Forensic application of VEGF expression to skin wound age determination. Int J Legal Med 2004;118:320–5. DOI: https://doi.org/10.1007/s00414-004-0468-x

Grellner W, Vieler S, Madea B. Transforming growth factors (TGFalpha and TGF-beta1) in the determination of vitality and wound age: immunohistochemical study on human skin wounds. Forensic Sci Int 2005;153:174–80. DOI: https://doi.org/10.1016/j.forsciint.2004.08.021

Kondo T, Tanaka J, Ishida Y, Mori R, Takayasu T, Ohshima T.Ubiquitin expression in skin wounds and its application to forensic wound age determination. Int J Legal Med 2002;116:267–72. DOI: https://doi.org/10.1007/s00414-002-0322-y

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Grellner W. Time-dependent immunohistochemical detection of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) in human skin wounds. Forensic Sci Int 2002:4;130(2-3):90-6. DOI: https://doi.org/10.1016/S0379-0738(02)00342-0

Fronczek J, Lulf R, Korkmaz HI, Witte BI, van de Goot FR, Begieneman MP, Schalkwijk CG, Krijnen PA, Rozendaal L, Niessen HW, Reijnders UJ. Analysis of inflammatory cells and mediators in skin wound biopsies to determine wound age in living subjects in forensic medicine. Forensic Sci Int 2015;247:7-13. DOI: https://doi.org/10.1016/j.forsciint.2014.11.014

Fronczek J, Lulf R, Korkmaz HI, Witte BI, van de Goot FR, Begieneman MP, Krijnen PA, Rozendaal L, Niessen HW, Reijnders UJ. Analysis of morphological characteristics and expression levels of extracellular matrix proteins in skin wounds to determine wound age in living subjects in forensic medicine. Forensic Sci Int 2015; 246:86-91. DOI: https://doi.org/10.1016/j.forsciint.2014.11.013

Yagi Y, Murase T, Kagawa S, Tsuruya S, Nakahara A, Yamamoto T, Umehara T, Ikematsu K. Immunohistochemical detection of CD14 and combined assessment with CD32B and CD68 for wound age estimation. Forensic Sci Int 2016: 4;262:113-120. DOI: https://doi.org/10.1016/j.forsciint.2016.02.031

van de Goot FR, Korkmaz HI, Fronczek J, Witte BI, Visser R, Ulrich MM, Begieneman MP, Rozendaal L, Krijnen PA, Niessen HW. A new method to determine wound age in early vital skin injuries: a probability scoring system using expression levels of Fibronectin, CD62p and Factor VIII in wound hemorrhage. Forensic Sci Int. 2014;244:128-35 DOI: https://doi.org/10.1016/j.forsciint.2014.08.015

Casse JM, Martrille L, Vignaud JM, Gauchotte G. Skin wounds vitality markers in forensic pathology: An updated review. Med Sci Law. 2015:21. pii: 0025802415590175. DOI: https://doi.org/10.1177/0025802415590175

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Kondo T, Ishida Y. Molecular pathology of wound healing. Forensic Sci Int 2010:15;203(1-3):93-8 DOI: https://doi.org/10.1016/j.forsciint.2010.07.004

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Sato Y, Ohshima T. The expression of mRNA of proinflammatory cytokines during skin wound healing in mice: a preliminary study for forensic wound age estimation (II). Int J Legal Med 2000;113(3):140-5. DOI: https://doi.org/10.1007/s004140050285

Takamiya M, Fujita S, Saigusa K, Aoki Y. A study on mRNA expressions of interleukin 10 during fracture healing for wound age determination. Leg Med (Tokyo). 2008;10(3):131-7. DOI: https://doi.org/10.1016/j.legalmed.2007.11.003

Takamiya M, Saigusa K, Nakayashiki N, Aoki Y. Studies on mRNA expression of basic fibroblast growth factor in wound healing for wound age determination. Int J Legal Med. 2003;117(1):46-50. DOI: https://doi.org/10.1007/s00414-002-0354-3

Takamiya M, Saigusa K, Kumagai R, Nakayashiki N, Aoki Y.Studies on mRNA expression of tissue-type plasminogen activator in bruises for wound age estimation. Int J Legal Med. 2005;119(1):16-21. DOI: https://doi.org/10.1007/s00414-004-0453-4

Kagawa S, Matsuo A, Yagi Y, Ikematsu K, Tsuda R, Nakasono I.The time-course analysis of gene expression during wound healing in mouse skin. Leg Med (Tokyo). 2009;11(2):70-75. DOI: https://doi.org/10.1016/j.legalmed.2008.09.004

Sun JH, Wang YY, Zhang L, Gao CR, Zhang LZ, Guo Z.Time-dependent expression of skeletal muscle troponin I mRNA in the contused skeletal muscle of rats: a possible marker for wound age estimation. Int J Legal Med.2010 ;124(1):27-33. DOI: https://doi.org/10.1007/s00414-009-0323-1

Açıkgöz NH, Kılınçarslan LE, Açıkgöz A, Bilge Y. Yara Yaşı Tahmininde RNA’nın Kullanımı. Türkiye Kinikleri J Foren Med 2012:9(1):37-41.

Wolfgang G, Burkhard M. Demands on scientific studies: Vitality of wounds and wound age estimation, Forensic Sci Int. 2007:17;165(2-3):150-154. DOI: https://doi.org/10.1016/j.forsciint.2006.05.029