Pulmonary Birefringent Material in Fatal Heroin Overdose
DOI:
https://doi.org/10.17986/blm.2005102585Keywords:
heroin, lung, foreign body, birefringent materialAbstract
Fatal heroin overdose is one of the major preventable causes of deaths. The mechanism of death for fatal heroin overdose has not been adequately explained yet. The noncardiogenic pulmonary edema is the most striking finding. On the other hand, lungs may exhibit granulomatous reactions in chronic abuse. In this study, histopathological cross-sections taken from the lungs of heroin intoxication overdose cases, whose previous postmortem examinations of the cases had been performed at the Mortuary Department of the Council of Forensic Medicine, were reevaluated. Twenty medicolegal cases without known heroin abuse history were evaluated as control group. The specimens were examined under polarizing light and foreign bodies were encountered in 15 of the 86 cases.
Key words: Heroin, lung, foreign body, biréfringent material
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Toprak S, Günaydın U, Ersoy G, Akgül E. Heroin overdose deaths and quality of heroin. Preceedings of the 3rd European Academy of Forensic Science Meeting. 2003 İstanbul. Forensic Sei Int 2003; 136(Suppl 1):311.
Darke S, Zador D. Fatal heroin “overdose”:A review. Addiction, 1996; 91(12):1765-1772. DOI: https://doi.org/10.1111/j.1360-0443.1996.tb03800.x
Andersen S.N, Skullerud K. Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts. Forensic Sei Int 1999;102:51-59. DOI: https://doi.org/10.1016/S0379-0738(99)00040-7
Wong LC, Chang H, Su JM, Wu TC, Tseng CH. Pulmonary granulomatosis associated with insoluble fillers in a heroin addict. J Formos Med Assoc 2003; 102(3):198-201.
Steensen P, Jorgensen HS, Juhl B. Heroin-induced pulmonary edema. Ugeskr Laeger, 1993; 13; 155(37): 2866-2868.
Ortega CJ, Prieto RS, Rodriguez GJ, Paylos GJ. Severe medical sequelae in heroin addicts. Med Clin (Bare) 1981;10;76(5):206-210.
Sporer KA, Dorn E. Heroin-related noncardiogenic pulmonary edema: A case series. Chest 2001; 120(5):1628-1632. DOI: https://doi.org/10.1378/chest.120.5.1628
Dettmeyer R, Schmidt P, Musshoff F, Dreisvogt C, Madea B. Pulmonary edema in fatal heroin overdose: Immunohistological investigations with IgE, collagen IV and laminin-no increase of defects of alveolar-capillary membranes. Forensic Sei Int 2000;110(2):87-96. DOI: https://doi.org/10.1016/S0379-0738(00)00148-1
Kringsholm B, Christoffersen P. Lung and heart pathology in fatal drug addiction. A consecutive autopsy study. Forensic Sei Int 1987; 34(l-2):39-51. DOI: https://doi.org/10.1016/0379-0738(87)90082-X
Warthin AS. Microscopic examination, in Finkbei- ner WE, Ursell PC, Dais RL. Autopsy Pathology, A Manual and Atlas. Philadelphia, Churcill Livingstone, 2004:105-126.
Corrin B. Pathology of the Lungs. Edinburg, Churchill Livingstone, 2000:370-371.
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