A Medicolegal Autopsy for a Rabies Infection Case
DOI:
https://doi.org/10.17986/blm.200382497Keywords:
rabies, autopsy, biosafetyAbstract
Rabies is an acute viral infectious disease with the highest mortality rate The causative agent is a neurotropic RNA virus in the family of Rhabdoviridae genus Lyssa virus. According to the records of Ministry of Health in Turkey; 529 people died from rabies between 1973-2001. It is estimated that human cases associated with rabies occur with an incidence of 25000 per year. Our case was a 21 years old male. He had a history of dog bite at the frontal site of his head and death occured within 25 days despite the prophylaxis. If a case is suspected to be dead because of infectious diseases, an autopsy can be performed without permission of relatives, by demand of officers, only. Spesific laboratory tests should also be done as a component of autopsy procedures in cases of human deaths associated with rabies. Autopsy team must be aware of the risk of transmission of virus and standard protocoles must be followed in disenfection of autopsy room, and instruments, and also in handling tissue samples. In this case, our purpose was to investigate and discuss the factors that may cause death in cases of rabies in spite of prophylaxis and highlight the biosafety considerations during autopsy in cases with suspicion of rabies.
Key words: Rabies, autopsy, biosafety
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El S, Kaptan F, Baran N, Ural S. 1986-1990 yılları arasında Atatürk Sağlık Sitesi İzmir Devlet Hastanesi İntaniye Kliniğinde izlenen 12 kuduz ön tamlı olgunun değerlendirilmesi. Atatürk Sağlık Sitesi İzmir Devlet Hastanesi Tıp Dergisi, 1992; 30: 64-66.
Göktaş P, Özyürek S, Karagül E, Sarı A. Kliniğimizde izlenen yedi insan kuduzu olgusu. Klimik Dergisi, 1995; 8:120-121.
Meço O.: Kuduz. http://www.infeksiyon.org/Deta- il.asp?ctg= 12&Article = 202 Son Erişim Tarihi; 20.08.2003.
Serter F, Serter D.: Klinik Viroloji. Bornova, Ege Üniversitesi Basımevi, 1980: 215-233.
Rupprecht CE, Hanlon CA, Hemachudha T.: Rabies reexamined. The Lancet Infectious Disease, 2002; 2: 327- 343. DOI: https://doi.org/10.1016/S1473-3099(02)00287-6
Temel Sağlık Hizmetleri Genel Müdürlüğü Çalışma Yıllığı.: 2001. http://www.saglik.gov.tr/sb/default.aspPsay- fa=istatistik&id = 108&kelime = &page Son Erişim Tarihi; 20.08.2003.
Güzel T, Aylan O. Kuduz hastalığının laboratuvar teşhisinde floresan antikor, fare inokülasyon testi ve kuduz doku kültürü enfeksiyon testlerinin karşılaştırılması. Etlik Veteriner Mikrobiyoloji Dergisi, 1995; 8: 45-55.
Soysal Z, Eke SM, Çağdır AS.: Adli Otopsi Cilt 1. İstanbul: İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Yayınları, 1999: 55-57.
Bodur S.: Ankara’da hayvan ısırıkları (1989). Türk Hijyen ve Deneysel Biyoloji Dergisi, 1990; 47: 225-233.
Tümerdem Y, Ayhan B, Kosku N, Aslantürk F, Sur H, Erbaydar T. Kuduzda bağışıklama (İstanbul'da Epidemi- yolojik Bir Çalışma). Ankern Dergisi, 1992; 6: 233.
Şenol E.: Kuduz (Rabies). Sürekli Tıp Eğitimi Dergisi, 1993; 2: 370-372.
Winkler WG, Fashinell TR, Leffingwell L, Howard P, Conomy P.: Airborne rabies transmission in a laboratory worker. JAMA, 1973; (226): 1219-1221. DOI: https://doi.org/10.1001/jama.226.10.1219
Nolte KB,Taylor DG, Richmond JY.: Biosafety considerations for autopsy. Am J Forensic Med Pathol, 2002; 23: 107-122. DOI: https://doi.org/10.1097/00000433-200206000-00001
Braude AI, Davis CE, Fierer J.: Infectious Dieases and Medical Microbiology. Second edition. Philadelphia: W.B. Saunders Company, 1986: 1109-1114.
Ustaçelebi Ş.: Temel ve Klinik Mikrobiyoloji. Ankara: Güneş Kitapevi Ltd. Şti, 1999: 981-5.
Smith J, McElhinney L, Parsons G, Brink N, Doherty T, Agranoff D, Miranda ME, Fooks AR.: Case report: Rapid ante-mortem diagnosis of a human case of rabies imported into the UK from the Philippines. Journal of Medical Virology, 2003; 59: 150-155. DOI: https://doi.org/10.1002/jmv.10253
Mandell GL, Douglas Jr. RG, Bennet JE.: Principles and Practise of Infectious Disease. Third edition. New York: Churchill Livingstone, 1990: 1296-1297.
David D, Yakobson B, Rotenberg D, Dveres N, Davidson I, Stram Y.: Rabies virus detection by RT-PCR in decomposed naturaly indected brains. Veterinary Microbiology, 2002; 87: 111-118. DOI: https://doi.org/10.1016/S0378-1135(02)00041-X
Leech RW.: Electron-microscopic study of the inclusion body in human rabies. Neurology, 1971; 21: 91-94. DOI: https://doi.org/10.1212/WNL.21.1.91
Warner CK, Whitfield SG, Fekadu M, Ho H.: Procedures for reproducible detection of rabies virus antigen mRNA and genome in situ in formalin-fixed tissues. J, of Virological Methods, 1997; 67: 5-12. DOI: https://doi.org/10.1016/S0166-0934(97)00068-2
Topçu AW, Söyletir G, Doğanay M.: İnfeksiyon Hastalıkları. İstanbul: Nobel Tıp Kitapevleri, 1996: 891-892.
Duenas A, Belsey MA, Escobar J, Medina P, Sanmartin C.: Isolation of rabies virus outside the human central nervous system. The Journal of Infectious Disease, 1973; 127: 702-704. DOI: https://doi.org/10.1093/infdis/127.6.702
Cheetham HD, Hart J, CoghiU NF, Fox B.: Rabies with myocarditis two cases in England. The Lancet, 1970;2: 921-922. DOI: https://doi.org/10.1016/S0140-6736(70)91048-2
Anderson WAD, Kissane JM.: Anderson’s Pathology Volume One. Eighth edition. ST. Louis: The C.V. Mosby Company, 1985: 352.
Dolman CL, Charlton KM.: Massive necrosis of the brain in rabies. The Canadian Journal of Neurological Science, 1987; 14: 162-165. DOI: https://doi.org/10.1017/S0317167100026329
Işık AF, Tekin İÖ, Demirel B, Işık M.: Seroprevelance of HIV, HBV and HCV in Forensic Autopsies in Ankara. Current Topics in Forensic Science Proceedings of the 14th Meeting of the International Association of Forensic Sciences. Canada: Shunderson Communications, 1997: 272-275.
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