The Tree That Leads to Death: Yew Fruit
Yew Fruit
DOI:
https://doi.org/10.17986/blm.1554Keywords:
Yew Tree Fruit, Cardiotoxicity, Sudden DeathAbstract
Yew fruit can cause a large number of human and animal poisoning and can be highly toxic. This is achieved by the taxon alkaloids (Taxin A and Taxin B) that cause cardiotoxic effects in its structure. Taxins cause cardiac dysrhythmia with the effect of calcium channel antagonism in cardiac myocytes and cause a clinical deterioration leading to death. The diagnosis of yew fruit poisoning is usually made by identifying plant parts in the digestive system. With the recent technological developments and the development of toxicological diagnosis methods, the diagnosis of metabolites in lower doses has begun to be made more easily with clinical suspicion.
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Trees Of Life [Internet]. Mythology and folklore of yew. [cited 2021 Jan 31]. Available from:https://treesforlife.org.uk/into-the-forest/trees-plants-animals/trees/yew/. [Çevrimiçi]
Di̇keş S, Yilmaz M, Kalkan M. Mustafakemalpaşa ve Karacabey’deki Taxus baccata L. Gen Kaynakları. Biyolojik Çeşitlilik ve Koruma. 2021;14: 146–154. Available: https://dergipark.org.tr/en/pub/biodicon/issue/59796/883497 DOI: https://doi.org/10.46309/biodicon.2021.883497
Sözcü. Bronz Çağı’ndan beri orada ve 4 bin 115 yaşında: Türkiye’nin en yaşlı ağacı Zonguldak’ta! In: Sözcü [Internet]. 30 Oct 2020 [cited 25 May 2021]. Available: https://www.sozcu.com.tr/hayatim/yasam-haberleri/bronz-cagindan-beri-orada-ve-4-bin-115-yasinda-turkiyenin-en-yasli-porsuk-agaci-zonguldakta/
4.Wilson CR, Hooser SB. Chapter 66 - Toxicity of Yew (Taxus spp.) Alkaloids. In: Gupta RC, editor. Veterinary Toxicology (Third Edition) [Internet]. Academic Press; 2018. p. 947–54. Available from: http://www.sciencedirect.com/science/article/pii/B978012811. DOI: https://doi.org/10.1016/B978-0-12-811410-0.00066-0
Fröhne D, Pfänder J. Taxaceae, Taxus baccata L., yew. In A Colour Atlas of Poisonous Plants, 2nd ed. Wolfe Publishing Ltd., London; 1984. p. 223–225.
Foster S, Duke JA. American yew. In Eastern/Central Medicinal Plants. Houghton Mifflin, Boston, MA;1990.p.226.
Hartzell H. Yew and us: a brief history of the yew tree. In Taxol: Science and Applications, Suffness M (ed.). CRC Press, Boca Raton, FL;1995. p. 27–34. DOI: https://doi.org/10.1201/9780138737361-3
Watt JM, Breyer-Brandwijk MG. Taxaceae. In The Medicinal and Poisonous Plants of Southern and Eastern Africa. E&S Livingstone, Edinburgh;1962. p.1019–1022.
Bryan-Brown T. The pharmacological actions of taxine. Quaterly J of Pharmacy and Pharmacol. 1932;5:205–19.
Akbar S. Taxus baccata L. (Taxaceae). In: Akbar S, editor. Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications [Internet]. Cham: Springer International Publishing; 2020. p. 1753–61. Available from: https://doi.org/10.1007/978-3-030-16807-0_181 : yazarı bilinmiyor. DOI: https://doi.org/10.1007/978-3-030-16807-0_181
Krenzelok EP, Jacobsen TD, Aronis J. Is the Yew Really Poisonous to You? J Toxicol Clin Toxicol [Internet]. 1998 Jan 1;36(3):219–23. Available from: https://doi.org/10.3109/15563659809028942. DOI: https://doi.org/10.3109/15563659809028942
Labossiere AW, Thompson DF. Clinical Toxicology of Yew Poisoning. Ann Pharmacother [Internet]. 2018 Jun 1;52(6):591–9. Available from: https://doi.org/10.1177/1060028017754225. DOI: https://doi.org/10.1177/1060028017754225
Piskač O, Stříbrný J, Rakovcová H, Malý M. Cardiotoxicity of yew. Cor Vasa [Internet]. 2015 Jun 1;57(3):e234–8. Available from: http://www.sciencedirect.com/science/article/pii/S0010865014000952. DOI: https://doi.org/10.1016/j.crvasa.2014.11.003
Porter KA, Kroll S. Yew berry ingestion [Internet]. Vol. 284, BMJ. 1982. p. 116–116. Available from: http://dx.doi.org/10.1136/bmj.284.6309.116-c. DOI: https://doi.org/10.1136/bmj.284.6309.116-c
Cummins RO, Haulman J, Quan L, Graves JR, Peterson D, Horan S. Near-fatal yew berry intoxication treated with external cardiac pacing and digoxin-specific FAB antibody fragments. Ann Emerg Med [Internet]. 1990 Jan;19(1):38–43. . Available from: http://dx.doi.org/10.1016/s0196-0644(05)82138-9. DOI: https://doi.org/10.1016/S0196-0644(05)82138-9
Feldman R, Szajewski JM, Chrobak J, Liberek ZM. Four cases of self-poisoning with yew leaves decoction. Veterinary and Human Toxicology[VET HUM TOXICOL ]. 1987;29(2).
Grobosch T, Schwarze B, Felgenhauer N, Riesselmann B, Roscher S, Binscheck T. Eight cases of fatal and non-fatal poisoning with Taxus baccata [Internet]. Vol. 227, Forensic Science International. 2013. p. 118–26. Available from: http://dx.doi.org/10.1016/j.forsciint.2012.11.014. DOI: https://doi.org/10.1016/j.forsciint.2012.11.014
Fuchs J, Rauber-Lüthy C, Kupferschmidt H, Kupper J, Kullak-Ublick G-A, Ceschi A. Acute plant poisoning: analysis of clinical features and circumstances of exposure. Clin Toxicol [Internet]. 2011 Aug;49(7):671–80. . Available from: http://dx.doi.org/10.3109/15563650.2011.597034 : yazarı bilinmiyor. DOI: https://doi.org/10.3109/15563650.2011.597034
Malkoc M.A., Uzun I. Porsuk Ağacı Zehirlenmesine Bağlı Ani Ölüm. Olgularla Adli Tıp ve Adli Bilimler. (2020)55:pp.381-389.
Hilger A, Brande F. Ueber Taxin, das Alkaloïd des Eibenbaumes (Taxus baccata). Ber Dtsch Chem Ges [Internet]. 1890 Jan;23(1):464–8. Available from: http://doi.wiley.com/10.1002/cber.18900230179. DOI: https://doi.org/10.1002/cber.18900230179
Graf E, Boeddeker H. Zur Kenntnis der β-Dimethylamino-hydrozimtsäure (Taxus-Alkaloide, 1. Mitteilung). Arch Pharm [Internet]. 1956;289(7):364–70. Available from: http://doi.wiley.com/10.1002/ardp.19562890707. DOI: https://doi.org/10.1002/ardp.19562890707
Graf E, Bertholdt H. Das amorphe taxin und das kristallisierte taxin A. Pharm Zentralhalle Dtschl. 1957;96:385–95.
Yared JA, Tkaczuk KHR. Update on taxane development: new analogs and new formulations. Drug Des Devel Ther [Internet]. 2012 Dec 11;6:371–84. Available from: http://dx.doi.org/10.2147/DDDT.S28997. DOI: https://doi.org/10.2147/DDDT.S28997
Stage TB, Bergmann TK, Kroetz DL. Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review. Clin Pharmacokinet [Internet]. 2018 Jan;57(1):7–19. Available from: http://dx.doi.org/10.1007/s40262-017-0563-z. DOI: https://doi.org/10.1007/s40262-017-0563-z
Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma [Internet]. Vol. 5, Nature Reviews Disease Primers. 2019. Available from: http://dx.doi.org/10.1038/s41572-019-0060-9. DOI: https://doi.org/10.1038/s41572-019-0060-9
Barata PC, Sartor AO. Metastatic castration-sensitive prostate cancer: Abiraterone, docetaxel, or…. Cancer [Internet]. 2019 Jun 1;125(11):1777–88. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32039. DOI: https://doi.org/10.1002/cncr.32039
Gustafson DL, Long ME, Zirrolli JA, Duncan MW, Holden SN, Scott Pierson A, et al. Analysis of docetaxel pharmacokinetics in humans with the inclusion of later sampling time-points afforded by the use of a sensitive tandem LCMS assay [Internet]. Vol. 52, Cancer Chemotherapy and Pharmacology. 2003. p. 159–66. Available from: http://dx.doi.org/10.1007/s00280-003-0622-z. DOI: https://doi.org/10.1007/s00280-003-0622-z
Baker SD, Sparreboom A, Verweij J. Clinical pharmacokinetics of docetaxel : recent developments. Clin Pharmacokinet [Internet]. 2006;45(3):235–52. Available from: http://dx.doi.org/10.2165/00003088-200645030-00002. DOI: https://doi.org/10.2165/00003088-200645030-00002
Łukasik-Głebocka M, Sieńko A, Klimaszyk D, Mańkowski W. [Effective intracavitary pacemaking for Taxus baccata-induced cardiac conduction defects and arrhythmias]. Przegl Lek [Internet]. 2007;64(4-5):298–300. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17724890.
Wilson CR, Sauer J-M, Hooser SB. Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids [Internet]. Vol. 39, Toxicon. 2001. p. 175–85. Available from: http://dx.doi.org/10.1016/s0041-0101(00)00146-x. DOI: https://doi.org/10.1016/S0041-0101(00)00146-X
Zutter A, Hauri K, Evers KS, Uhde S, Fassl J, Reuthebuch OT, et al. “Chaotic Arrhythmia” During Successful Resuscitation After Ingestion of Yew (Taxus baccata) Needles [Internet]. Vol. Publish Ahead of Print, Pediatric Emergency Care. 2017. Available from: http://dx.doi.org/10.1097/pec.0000000000001196 : yazarı bilinmiyor. DOI: https://doi.org/10.1097/PEC.0000000000001196
Lassnig E, Heibl C, Punzengruber C, Eber B. ECG of a “dying heart” in a young woman — A case of yew poisoning [Internet]. Vol. 167, International Journal of Cardiology. 2013. p. e71–3. Available from: http://dx.doi.org/10.1016/j.ijcard.2013.03.106. DOI: https://doi.org/10.1016/j.ijcard.2013.03.106
Soumagne N, Chauvet S, Chatellier D, Robert R, Charrière J-M, Menu P. Treatment of yew leaf intoxication with extracorporeal circulation. Am J Emerg Med [Internet]. 2011 Mar;29(3):354.e5–6. Available from: http://dx.doi.org/10.1016/j.ajem.2010.03.017. DOI: https://doi.org/10.1016/j.ajem.2010.03.017
Panzeri C, Bacis G, Ferri F i wsp. Extracorporeal life suport in a severe Taxus baccata poisoning. Clin Toxicol (Phila) 2010; 48: 463-465. doi: 10.3109/15563650.2010.487487. DOI: https://doi.org/10.3109/15563650.2010.487487
Dahlqvist M, Venzin R, König S, Faber K, Weinmann W, Terbeck S, et al. Haemodialysis in Taxus baccata poisoning: a case report. QJM [Internet]. 2012 Apr;105(4):359–61. Available from: http://dx.doi.org/10.1093/qjmed/hcr037. DOI: https://doi.org/10.1093/qjmed/hcr037
Reijnen G, Bethlehem C, van Remmen JMBL, Smit HJM, van Luin M, Reijnders UJL. Post-mortem findings in 22 fatal Taxus baccata intoxications and a possible solution to its detection. J Forensic Leg Med [Internet]. 2017 Nov 1;52:56–61. Available from: http://www.sciencedirect.com/science/article/pii/S1752928X17301300. DOI: https://doi.org/10.1016/j.jflm.2017.08.016
Froldi R, Croci PF, Dell’Acqua L, Farè F, Tassoni G, Gambaro V. Preliminary Gas Chromatography with Mass Spectrometry Determination of 3,5-dimethoxyphenol in Biological Specimens as Evidence of Taxus Poisoning* [Internet]. Vol. 34, Journal of Analytical Toxicology. 2010. p. 53–6. Available from: http://dx.doi.org/10.1093/jat/34.1.53. DOI: https://doi.org/10.1093/jat/34.1.53
Frommherz L, Kintz P, Kijewski H, Köhler H, Lehr M, Brinkmann B, et al. Quantitative determination of taxine B in body fluids by LC–MS–MS [Internet]. Vol. 120, International Journal of Legal Medicine. 2006. p. 346–51. Available from: http://dx.doi.org/10.1007/s00414-005-0071-9.
Arens AM, Anaebere TC, Horng H, Olson K. Fatal Taxus baccata ingestion with perimortem serum taxine B quantification. Clin Toxicol [Internet]. 2016 Nov;54(9):878–80. Available from: http://dx.doi.org/10.1080/15563650.2016.1209765. DOI: https://doi.org/10.1080/15563650.2016.1209765
Hendrikx J, Rosing H, Schinkel AH, Schellens JHM, Beijnen JH. Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays [Internet]. Vol. 6, Bioanalysis. 2014. p. 993–1010. Available from: http://dx.doi.org/10.4155/bio.14.48. DOI: https://doi.org/10.4155/bio.14.48
Tranca S, Petrisor CL. A fatal case of Taxus poisoning. Clujul Med [Internet]. 2013 Aug 5;86(3):279–81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26527962.
Beyer J, Drummer OH, Maurer HH. Analysis of toxic alkaloids in body samples [Internet]. Vol. 185, Forensic Science International. 2009. p. 1–9. Available from: http://dx.doi.org/10.1016/j.forsciint.2008.12.006. DOI: https://doi.org/10.1016/j.forsciint.2008.12.006
Frommherz L, Kintz P, Kijewski H, Köhler H, Lehr M, Brinkmann B, et al. Quantitative determination of taxine B in body fluids by LC–MS–MS [Internet]. Vol. 120, International Journal of Legal Medicine. 2006. p. 346–51. Available from: http://dx.doi.org/10.1007/s00414-005-0071-9. DOI: https://doi.org/10.1007/s00414-005-0071-9
Willaert W, Claessens P, Vankelecom B, Vanderheyden M. Intoxication with Taxus Baccata: Cardiac Arrhythmias Following Yew Leaves Ingestion [Internet]. Vol. 25, Pacing and Clinical Electrophysiology. 2002. p. 511–2. Available from: http://dx.doi.org/10.1046/j.1460-9592.2002.00511.x. DOI: https://doi.org/10.1046/j.1460-9592.2002.00511.x
Gausterer C, Stein C, Stimpfl T. Application of direct PCR in a forensic case of yew poisoning [Internet]. Vol. 126, International Journal of Legal Medicine. 2012. p. 315–9. Available from: http://dx.doi.org/10.1007/s00414-011-0607-0. DOI: https://doi.org/10.1007/s00414-011-0607-0
Pilz B, Mesner C, Baetgen S, Luft FC. Coma in a park [Internet]. Vol. 354, The Lancet. 1999. p. 1090. Available from: http://dx.doi.org/10.1016/s0140-6736(99)08180-5. DOI: https://doi.org/10.1016/S0140-6736(99)08180-5
Persico A, Bacis G, Uberti F, Panzeri C, Di Lorenzo C, Moro E, et al. Identification of Taxine Derivatives in Biological Fluids from a Patient after Attempted Suicide by Ingestion of Yew (Taxus baccata) Leaves [Internet]. Vol. 35, Journal of Analytical Toxicology. 2011. p. 238–41. Available from: http://dx.doi.org/10.1093/anatox/35.4.238. DOI: https://doi.org/10.1093/anatox/35.4.238
Pierog JE, Kane B, Kane K, Donovan JW. Management of isolated yew berry toxicity with sodium bicarbonate: A case report in treatment efficacy. J Med Toxicol [Internet]. 2009 Jun 1;5(2):84. Available from: https://doi.org/10.1007/BF03161094. DOI: https://doi.org/10.1007/BF03161094
Graeme KA, Ruha A-M, Tanen DA, Curry SC, Miller MB, Gerkin R, et al. Hypertonic Sodium Bicarbonate for Taxus media-induced Cardiac Toxicity in Swine [Internet]. Vol. 9, Academic Emergency Medicine. 2002. p. 179–85. Available from: http://dx.doi.org/10.1197/aemj.9.3.179. DOI: https://doi.org/10.1197/aemj.9.3.179
Patel N, Bayliss GP. Developments in extracorporeal therapy for the poisoned patient [Internet]. Vol. 90, Advanced Drug Delivery Reviews. 2015. p. 3–11. Available from: http://dx.doi.org/10.1016/j.addr.2015.05.017. DOI: https://doi.org/10.1016/j.addr.2015.05.017
Bayliss G. Dialysis in the poisoned patient. Hemodial Int [Internet]. 2010 Apr;14(2):158–67. Available from: http://dx.doi.org/10.1111/j.1542-4758.2009.00427.x. DOI: https://doi.org/10.1111/j.1542-4758.2009.00427.x
Bugajski J, Sacha J. Brugada electrocardiography pattern caused by Taxus poisoning. Kardiol Pol [Internet]. 2015;73(6):463. Available from: http://dx.doi.org/10.5603/KP.2015.0106. DOI: https://doi.org/10.5603/KP.2015.0106
Thooft A, Goubella A, Fagnoul D, Taccone FS, Brimioulle S, Vincent J-L, et al. Combination of veno-arterial extracorporeal membrane oxygenation and hypothermia for out-of-hospital cardiac arrest due to Taxus intoxication. CJEM [Internet]. 2014 Nov;16(6):504–7. Available from: http://dx.doi.org/10.1017/s1481803500003559. DOI: https://doi.org/10.1017/S1481803500003559
Bounes FV, Tardif E, Ruiz S, Gallart J-C, Conil J-M, Delmas C. Suicide attempt with self-made Taxus baccata leaf capsules: survival following the application of extracorporeal membrane oxygenation for ventricular arrythmia and refractory cardiogenic shock. [Internet]. Vol. 55, Clinical Toxicology. 2017. p. 925–8. Available from: http://dx.doi.org/10.1080/15563650.2017.1321763 DOI: https://doi.org/10.1080/15563650.2017.1321763
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