Current Problems in the Use of Illegal Substances Ingredients
DOI:
https://doi.org/10.17986/blm.201217213Keywords:
illegal substances, impurities, toxic effects, adulterantsAbstract
It is known that many diluents and adulterants are used to make illegal substances appear in larger amount and bring more profit. Identification of such additives in illegal substances is particularly important, since some of the toxic effects of such compounds are much more harmful than impact of illegal substances used. The unpredictable substances may endanger the lives of illegal substance users. In this study, the content of two samples brought with suspected illegal substance were investigated and in Sample 1, paracetamol, caffeine and griseofulvin, other the hand in Sample 2 phenacetin were determined as adulterants. Increasing of the contents and ratio of the adulterants in these illegal substances day by day, it should be considered that these additives should also be taken into account in the case of an unexpected death or permanent damage. The findings were evaluated with the groups who have done similar studies in terms of change in content of adulterants and possible health risks, which they may caused.
Keywords: Illegal substances; impurities; toxic effects; adulterants
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References
Kaa E. Impurities, adulterants and diluents of illicit heroin: changes during a 12-year period. Forensic Sci Int 1994;64:171-179. DOI: https://doi.org/10.1016/0379-0738(94)90228-3
Fucci N, Giovanni N. Adulterants encountered in the illicit cocaine market. Forensic Sci Int 1998; 95:247-252. DOI: https://doi.org/10.1016/S0379-0738(98)00102-9
Kaa E, Kaempe B. Impurities, adulterants and diluents of illicit heroin in Denmark (Jutland and Funen). Forensic Sci Int 1986;31:195-210. DOI: https://doi.org/10.1016/0379-0738(86)90188-X
Van der Slooten EP, Van der Helm HJ. Analysis of heroin in relation to illicit drug traffic. Forensic Sci 1975;6:83-88. DOI: https://doi.org/10.1016/0300-9432(75)90226-5
Shesser R, Jotte R, Olshaker J. The contribution of impurities to the acute morbidity of illegal drug use. Am J Emerg Med 1991;9(4):336-342. DOI: https://doi.org/10.1016/0735-6757(91)90053-M
Davies C, English L, Lodwick A, McVeigh J, Bellis MA. United Kingdom drug situation: Annual report to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) 2009. Liverpool: Liverpool John Moores University.
Australian Crime Commission. Illicit drug data report 2007-08. Canberra City: Australian Crime Commission, 2009.
Andreasen MF, Lindholst C, Kaa E. Adulterants and Diluents in Heroin, Amphetamine, and Cocaine Found on the Illicit Drug Market in Aarhus, Denmark. The Open Forensic Sci. J. 2009;2:16-20. DOI: https://doi.org/10.2174/1874402800902010016
http://news.bbc.co.uk/2/hi/uk/6178026.stm (son erişim tarihi: 13.12.2013)
http://www.emcdda.europa.eu/html.cfm/index191576EN.html (son erişim tarihi: 13.12.2013)
Hamilton RJ, Perrone J, Hoffman R, Henretig FM, Karkevandian EB, Marcus S, Shih RD, Blok B, Nordenholz K. A descriptive study of an epidemic caused by heroin adulterated with scopolamine. Clin Toxicol 2000;38(6):597-608. DOI: https://doi.org/10.1081/CLT-100102008
Centers for Disease Control and Prevention. Atypical reactions associated with heroin use – Five states, January – April 2005. Morbidity and Mortality Weekly Report 2005;54(32):793-796.
McKinney CD, Postiglione KF, Herold DA. Benzocaine-adulterated street cocaine in association with methemoglobinemia. Clin Chem 1992;38(4):596-597. DOI: https://doi.org/10.1093/clinchem/38.4.596
O’Callaghan WG, Joyce N, Counihan HE, Ward M, Lavelle M, O’Brien E. Unusual strychnine poisoning and its treatment: Report of eight cases. BMJ 1982;285(6340):478. DOI: https://doi.org/10.1136/bmj.285.6340.478
Knowles L, Buxton JA, Skuridina N, Achebe I, LeGatt D, Fan S, Zhu NY, Talbot J. Levamisole tainted cocaine causing severe neutropenia in Alberta and British Columbia. Harm Reduction Journal, 6(30). DOI: https://doi.org/10.1186/1477-7517-6-30
http://www.drugs.com/sfx/griseofulvin-side-effects.html (son erişim tarihi 13.12.2013)
Dubach U, Rosner B, Stürmer T. An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med 1991;324:155-160. DOI: https://doi.org/10.1056/NEJM199101173240304
Hughes J. Pain Management: From Basics to Clinical Practice. Elsevier Health Science, 2008.
Dukes MNG, Jeffrey KA. Meyler’s side Effects of Drugs, Vol XIV. Elsevier, 2000.
García Rodríguez LA, Hernández-Díaz S. The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Res Ther 2000;3:98-101. DOI: https://doi.org/10.1186/ar146
Michael S, Gross AD, Altman R. The Cancer Dictionary. Infobase Publishing, 2007.
http://news.bbc.co.uk/2/hi/health/3271191.stm (son erişim tarihi 13.12.2013)
Walter RB, Milano F, Brasky TM, White E. Long-term use of acetaminophen, aspirin, and other non-steroidal anti-inflammatory drugs and risk of hematologic malignancies: results from the prospective VITamins and Lifestyle (VITAL) study. J Clin Oncol 2011;29:2424–2431. DOI: https://doi.org/10.1200/JCO.2011.34.6346
Hughes J. Pain Management: From Basics to Clinical Practice. Elsevier Health Science, 2008.
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